聚苯乙烯基磁性纳米塑料磁共振成像效果分析

兰州理工大学学报 ›› 2023, Vol. 49 ›› Issue (5): 20-27.

聚苯乙烯基磁性纳米塑料磁共振成像效果分析

张龙^*1,2, 刘浩男^1,2, 高博^1,2, 辛琦^1,2, 唐洁^1,2, 艾纯金^1,2

1.兰州理工大学材料科学与工程学院, 甘肃兰州 730050;
2.兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室, 甘肃兰州 730050

收稿日期:2023-03-31 出版日期:2023-10-28 发布日期:2023-11-07
通讯作者: 张龙(1982-),男,博士,江苏徐州人,副教授. Email:zhanglong@lut.edu
基金资助:
国家自然科学基金(22066015)

Magnetic resonance imaging effect of polystyrene-based magnetic nanoplastics

ZHANG Long^1,2, LIU Hao-nan^1,2, GAO Bo^1,2, XIN Qi^1,2, TANG Jie^1,2, AI Chun-jin^1,2

1. School of Materials Science and Engineering, Lanzhou Univ. of Tech., Lanzhou 730050, China;
2. State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals, Lanzhou Univ. of Tech., Lanzhou 730050, China

Received:2023-03-31 Online:2023-10-28 Published:2023-11-07

摘要/Abstract

摘要： 为了用于高效的细胞磁共振成像(MRI),开发了基于聚苯乙烯/Fe₃O₄纳米粒子的T2加权造影剂.采用双细乳液聚合法和分散聚合法分别制备出两种不同尺寸的纳米塑料模型,并对其进行细胞磁共振成像.结果表明:随着纳米塑料模型暴露浓度的增加,标记的小鼠巨噬细胞伪彩图像显示出显著的负对比度增强,灰度图像暗度加强,MRI信号强度也随着浓度的增加逐渐降低.ICP分析结果证实了小鼠巨噬细胞摄取纳米塑料模型的量随着样品浓度的增加而增加,聚苯乙烯基磁性纳米塑料模型可以为纳米塑料的细胞MRI成像提供一个全新的视角.

关键词: 纳米塑料, 磁共振成像, 造影剂, 聚苯乙烯

Abstract: For efficient cellular magnetic resonance imaging (MRI), a T2-weighted contrast agent based on polystyrene/Fe₃O₄ nanoparticles was developed. Two kinds of nanoplastic models with different sizes were prepared by double miniemulsion polymerization and dispersion polymerization, respectively, and the cell MRI was performed on them. The results showed that: with the increase of the exposure concentration of the nano-plastic model, the pseudo-color images of labeled mouse macrophages showed significant negative contrast enhancement, enhanced darkness of the gray image, and a gradual decrease in the intensity of MRI signal. The results of the ICP analysis confirmed that the uptake of the nanoplastic model by mouse macrophages increased with the increase of sample concentration. The polystyrene magnetic nanoplastic model can provide a new perspective for the cell MRI imaging of nanoplastics.

Key words: nanoplastics, magnetic resonance imaging, contrast agents, polystyrene

中图分类号:

TB34

张龙, 刘浩男, 高博, 辛琦, 唐洁, 艾纯金. 聚苯乙烯基磁性纳米塑料磁共振成像效果分析[J]. 兰州理工大学学报, 2023, 49(5): 20-27.

ZHANG Long, LIU Hao-nan, GAO Bo, XIN Qi, TANG Jie, AI Chun-jin. Magnetic resonance imaging effect of polystyrene-based magnetic nanoplastics[J]. Journal of Lanzhou University of Technology, 2023, 49(5): 20-27.

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