1,3,5-三芳基吡唑衍生物的高效合成方法

兰州理工大学学报 ›› 2021, Vol. 47 ›› Issue (5): 65-69.

1,3,5-三芳基吡唑衍生物的高效合成方法

杨峥^*1,2, 解恒参¹, 丁维华¹, 赵明珠¹

1.江苏建筑职业技术学院江苏省生物质资源综合利用工程实验室, 江苏徐州 221116;
2.江苏师范大学化学与材料科学学院, 江苏徐州 221116

收稿日期:2021-04-26 出版日期:2021-10-28 发布日期:2021-11-18
通讯作者: 杨峥(1990-),女,江苏徐州人,博士,讲师.Email:yangzheng2245@126.com
基金资助:
江苏省高等学校自然科学研究重大项目(17KJA610001),江苏省高等学校自然科学研究面上项目(20KJB530014)

An efficient protocol for the synthesis of 1, 3, 5-triarylpyrazoles

YANG Zheng^1,2, XIE Heng-shen¹, DING Wei-hua¹, ZHAO Ming-zhu¹

1. Jiangsu Engineering Laboratory of Biomass Resources Comprehensive Utilization, Jiangsu Vocational Institute of Architectural Technology, Xuzhou 221116, China;
2. School of Chemistry & Materials Science, Jiangsu Normal University, Xuzhou 221116, China

Received:2021-04-26 Online:2021-10-28 Published:2021-11-18

摘要/Abstract

摘要： 以芳甲酰环氧乙烷和芳基肼为原料,微波辐射条件三乙胺促进下、乙醇溶剂中100 ℃经过原位开环/环化反应,合成了一系列三芳基吡唑衍生物,收率优良.单晶X-射线衍射确认了化合物3a的结构,所有产物的结构均经红外光谱、核磁共振氢谱和高分辨质谱证实.

关键词: 芳甲酰环氧乙烷, 芳基肼, 三芳基吡唑

Abstract: By using 2, 3-epoxypropan-1-one and arylhydrazine, trimethylamine-promoted in situ ring opening/cyclization reaction at100 ℃ was developed in ethanol under microwave irradiation, affording a series of triarylpyrazoles in good yields. Single crystal X-ray diffraction confirmed the structure of compound 3a. Furthermore, the structures of all products were characterized by infrared, nuclear magnetic, and high-resolution mass spectrometry.

Key words: 2,3-epoxypropan-1-one, arylhydrazine, triarylpyrazole

中图分类号:

O626

杨峥, 解恒参, 丁维华, 赵明珠. 1,3,5-三芳基吡唑衍生物的高效合成方法[J]. 兰州理工大学学报, 2021, 47(5): 65-69.

YANG Zheng, XIE Heng-shen, DING Wei-hua, ZHAO Ming-zhu. An efficient protocol for the synthesis of 1, 3, 5-triarylpyrazoles[J]. Journal of Lanzhou University of Technology, 2021, 47(5): 65-69.