Abstract: The 4-methyl-5-hydroxyethyl thiazole and p-cyanobenzyl cloride were taken as raw materials to synthesize a novel thiazolium salt of 3-(p-cyanobenzyl)-4-methyl-5-(2-hydroxyethyl)-1, 3-thiazolium chloride with microwave technique and then the VB1 was substituted by this thiazolium salt as catalyst of benzoin condensation reaction. Its catalytic performance was checked and it was found that when it was used to catalyze benzaldehyde, the benzoin would be obtained, with yield-rate of 74.5%; when it was used to catalyze furaldehyde, the furoin would be obtained, having yield-rate of 76.1%. This thiazolium salt would be not only without toxicity but also could be recovered and reused. The influence of a mount of substance putting ratio, reaction duration, reaction temperature, and power of microwave reactor on the yield-rate of this thiazolium salt was investigated. The purity of the resultant was determined with HPLC and the property of thiazolium salt and structure of benzoin were characterized by means of analysis of element composition and melting-point, IR, and LC-MS.

Key words: thiazolium salt, synthesis, benzoin condensation, catalytic function, microwave auxiliary