Magnetic resonance imaging effect of polystyrene-based magnetic nanoplastics

Abstract

Abstract: For efficient cellular magnetic resonance imaging (MRI), a T2-weighted contrast agent based on polystyrene/Fe₃O₄ nanoparticles was developed. Two kinds of nanoplastic models with different sizes were prepared by double miniemulsion polymerization and dispersion polymerization, respectively, and the cell MRI was performed on them. The results showed that: with the increase of the exposure concentration of the nano-plastic model, the pseudo-color images of labeled mouse macrophages showed significant negative contrast enhancement, enhanced darkness of the gray image, and a gradual decrease in the intensity of MRI signal. The results of the ICP analysis confirmed that the uptake of the nanoplastic model by mouse macrophages increased with the increase of sample concentration. The polystyrene magnetic nanoplastic model can provide a new perspective for the cell MRI imaging of nanoplastics.

Key words: nanoplastics, magnetic resonance imaging, contrast agents, polystyrene

CLC Number:

TB34

ZHANG Long, LIU Hao-nan, GAO Bo, XIN Qi, TANG Jie, AI Chun-jin. Magnetic resonance imaging effect of polystyrene-based magnetic nanoplastics[J]. Journal of Lanzhou University of Technology, 2023, 49(5): 20-27.

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