By using 2,3-epoxypropan-1-ones and enaminoketone, a PTSA-promoted in situ ring opening-hydrogen migration/intramolecular cyclization reaction at 100 ℃ was developed in DMF, affording a series of furano [3,4-b] pyridine derivatives in 70%~78% yields. The structures of all products were characterised by IR spectra, 1H NMR and HRMS. In addition, single-crystal X-ray diffraction confirmed the structure of compound 3a.
YANG Zheng
,
LIU Xue-jun
,
GAO Jiang
,
XIE Heng-shen
,
CONG Xing-shun
. An efficient protocol for the synthesis of furano [3,4-b] pyridine derivatives[J]. Journal of Lanzhou University of Technology, 2026
, 52(4)
: 66
-71
.
DOI: 10.13295/j.cnki.issn1673-5196.2026.04.008
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