An efficient protocol for the synthesis of furano [3,4-b] pyridine derivatives

doi:10.13295/j.cnki.issn1673-5196.2026.04.008

Journal of Lanzhou University of Technology ›› 2026, Vol. 52 ›› Issue (4): 66-71.doi: 10.13295/j.cnki.issn1673-5196.2026.04.008

• Chemical Industry and Light Industry • Previous Articles Next Articles

An efficient protocol for the synthesis of furano [3,4-b] pyridine derivatives

YANG Zheng^1,2,3, LIU Xue-jun¹, GAO Jiang¹, XIE Heng-shen², CONG Xing-shun³

1. School of Urban Safety and Operations, Jiangsu Vocational University of Architectural Technology, Xuzhou 221116, China;
2. Jiangsu Engineering Laboratory of Biomass Resources Comprehensive Utilization, Jiangsu Vocational University of Architectural Technology, Xuzhou221116, China;
3. College of Chemistry, Chemical Engineering and Materials Science, Zaozhuang University, Zaozhuang 277160, China

Received:2024-01-03 Online:2026-08-28 Published:2026-09-03

Abstract

Abstract: By using 2,3-epoxypropan-1-ones and enaminoketone, a PTSA-promoted in situ ring opening-hydrogen migration/intramolecular cyclization reaction at 100 ℃ was developed in DMF, affording a series of furano [3,4-b] pyridine derivatives in 70%~78% yields. The structures of all products were characterised by IR spectra,¹H NMR and HRMS. In addition, single-crystal X-ray diffraction confirmed the structure of compound 3a.

Key words: 2,3-epoxypropan-1-one, enaminoketone, furano [3,4-b] pyridine derivatives

CLC Number:

O626

YANG Zheng, LIU Xue-jun, GAO Jiang, XIE Heng-shen, CONG Xing-shun. An efficient protocol for the synthesis of furano [3,4-b] pyridine derivatives[J]. Journal of Lanzhou University of Technology, 2026, 52(4): 66-71.

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An efficient protocol for the synthesis of furano [3,4-b] pyridine derivatives

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